Correlation of Myopia Degree with Central Corneal Thickness and Corneal Endothelial Density
DOI:
https://doi.org/10.33096/gmj.v7i1.197Kata Kunci:
Myopia, refractive error, biometryAbstrak
Introduction: The anterior segment characteristics that may contribute to myopia are central corneal thickness and corneal endothelial cell density. The purpose of this study is to ascertain whether corneal endothelial density and central corneal thickness are associated with the degree of myopia.
Methods: This cross-sectional observational analytical study was conducted from October to November 2018 at the Hasanuddin University Hospital in Makassar, Indonesia. Levior myopia (< -3.00 D) 61 eyes, moderate myopia (-3.00 D - -6.00 D) 30 eyes, and gravior myopia (> 6.00 D) 11 eyes comprised the 102 eyes of 65 myopic patients who participated in the study. The Snellen chart projector and trial lens set are used to test the refractive state of myopia. In contrast, the Nidek-CEM 530 specular microscope is used to measure the central corneal thickness and corneal endothelial cell density.
Results: The high myopia group had the lowest CCT mean (521.3um; p: 0.199). The group with high myopia had the lowest mean ECD, 2777.6 (p<0.05). In cases of moderate myopia, a correlation between corneal ECD and CCT was found (p<0.05).
Conclusion: The degrees of myopia and the CCT do not correlate. Reductions in corneal ECD are associated with myopia gravior. In moderate myopia, there is a strong positive relationship between corneal endothelial cell density and central corneal thickness.
Referensi
Meng W, Butterworth J, Malecaze F and Calvas P 2010 Axial length: an underestimated endophenotype of myopia Med Hypotheses 74(2) 252-3
Goldschmidt E 2003 The mystery of myopia. Acta Ophthalmol Scand 81(5) 431-6
Pederson L, Hjortdal S and Ehlers N 2005 Central corneal thickness in high myopia Acta Ophthalmol Scand 83 539-42
Afifuddin M 2010 Hubungan antara umur dengan central corneal thickness, tekanan intraokuler dan lapangan pandang pada orang normal
Iyamu E and Memeh M 2007 The association of central corneal thickness with intra-ocular pressure and refractive error in a Nigerian Population.Online J Health Allied Scs 3 2
Touzeau O, Allouch C, Borderie V, Kopito R and Laroche L 2003 Corre´lation entre la re´fraction et la biome´ trie oculaire J Fr Ophtalmol 26 355–63
Alsbirk PH 1978 Corneal thickness. 1. Age variation, sex difference and oculometric correlations Acta Ophthalmol Scand 56(1) 95-104
Von Bahr G 1956 Corneal thickness: its measurement and changes Am J Ophthalmol 42(2) 251-66
Grosvenor T and Flom MC 1990 Refractive anomalies (Boston: Butterworth-Heineman) p 104–17
Chen Y, Kasuga T, Lee H, Lee S and Lin S. Correlation between central corneal thickness and myopia in taiwan Kaohsiung J Med Sci 30 20-4
Fam HB, How AC, Baskaran M, Lim KY, Chan YH and Aung T 2006 Central corneal thickness and its relationship to myopia in chinese adults’ Br J Ophthalmol 90 1451–3
Mohd-ali B, Ching HO and Latif NAA 2009 Corneal thickness and curvature of one sample of young myopic population in malaysia jurnal sains kesihatan malaysia 7(1) 49-58
Pedersen L, Hjortdal J and Ehlers N 2005 Central corneal thickness in high myopia Acta Ophthalmol. Scand. 83 539–42
Hiromi H 2014 Hubungan antara ketebalan kornea sentral dengan tekanan intra okuler pada pasien miopia. Makassar
Chang SW, Tsai IL, Hu FR, Lin LL and Shih YF 2001 The cornea in young myopic adult’s Br J Ophthalmol 85(8) 916-20
McBrien NA and Gentle A 2003 Role of the sclera in the development and pathological complications of myopia Prog Retin Eye Res 22(3) 307-338
Delshad S and Chun JM 2013 Corneal endothelial cell density and morphology in low and moderate myopic Chinese eyes Int J Ophthalmol 6(4) 467-470
Landesz M, Siertsema JV and Van Rij G 1995 Comparative study of three semiautomated specular microscopes J Cataract Refract Surg 21 409–16
Patel HY, DV Patel and CNJ McGhee 2009 Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults Eye 23 270–8
Matsuda M, Yee RW and Edelhauser HF 1985 Comparison of the corneal endothelium in an American and a Japanese population Arch Ophthalmol 103 68–70
