Association of Hyperuricemia with Hypertension in Adult without Major Metabolic Comorbidities
DOI:
https://doi.org/10.33096/azgh6141Keywords:
Hyperuricemia, hypertension, uric acid serum, metabolic risk factorAbstract
Introduction: Hypertension is a major global health problem and a leading cause of cardiovascular morbidity and mortality. Hyperuricemia has been increasingly recognized as a potential metabolic factor associated with elevated blood pressure, although its independent role remains unclear, particularly in individuals without obesity, diabetes mellitus, or chronic kidney disease (CKD).
Methods: Hypertension is a major global health problem and a leading cause of cardiovascular morbidity and mortality. Hyperuricemia has been increasingly recognized as a potential metabolic factor associated with elevated blood pressure, although its independent role remains unclear, particularly in individuals without obesity, diabetes mellitus, or chronic kidney disease (CKD).
Result: Hypertension occurred in 72.5% of participants with hyperuricemia compared with 25.0% without hyperuricemia. Hyperuricemia was significantly associated with hypertension (p < 0.001; contingency coefficient = 0.429). Participants with hyperuricemia had a 2.91-fold higher risk of hypertension (RR = 2.91; 95% CI: 1.64–5.13). This association persisted across age groups, with RR = 2.41 (95% CI: 1.31–4.44) in participants aged <60 years and RR = 3.73 (95% CI: 1.25–11.16) in those aged ≥60 years.
Conclusion: Hyperuricemia was associated with an increased risk of hypertension independent of major metabolic comorbidities and age, suggesting its potential role as an additional metabolic risk factor for hypertension.
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