Complications of Diabetes Mellitus: A Review Article
DOI:
https://doi.org/10.33096/gmj.v5i3.135Keywords:
Complications, diabetes mellitus, diabetic ketoacidosis, hyperglycemic hyperosmolar stateAbstract
Introduction: Diabetes Mellitus is a chronic disease that will be suffered for a lifetime so the progressive disease will continue and can cause complications. Diabetes mellitus usually progresses slowly with symptoms that are mild to severe and can even cause death due to acute or chronic complications.
Content: Hyperglycemic crisis is one of the acute complications that can occur in Diabetes mellitus, both type 1 and type 2. This situation is a serious complication that may occur even in well-controlled diabetes mellitus.
Conclusion: Diabetic ketoacidosis and hyperglycemic Hyperosmolar State are acute complications of Diabetes mellitus. Both of these complications can be triggered due to inadequate insulin therapy and the presence of infection. Diabetic ketoacidosis is a condition characterized by metabolic acidosis due to excessive formation of ketones, while a hyperglycemic hyperosmolar state is characterized by severe hyperosmolality with serum glucose levels which are usually higher than diabetic ketoacidosis.
References
World Health Organization. Monitoring Health for the SDGs. (Online). 2018.Available at: https://apps.who.int/iris/bitstream/handle/10665/272596/9789241565585eng.pdf?ua=. (Diakses pada 6 Juni 2021).
International Diabetes Federation. IDF Diabetes Atlas 9th Edition. (Online). 2019.Available at: www.diabetesatlas.org: 45-59. (Diakses pada 7 Juni 2021).
Dugan, Joy., & Shubrook, Jay. International classification of diseases-10 coding fordiabetes. Clinical Diabetes. 2017;35(4):232-238. Available at:https://doi.org/10.2337/cd16-0052.
LeMone, Priscilla., Burke, Karen, M., & Bauldoff, Gerene. Buku ajar keperawatanmedikal bedah (Edisi ke-5). 2016.
Gosmanov AR, Gosmanova EO, Kitabchi AE. Hyperglycemic Crises: DiabeticKetoacidosis and Hyperglycemic Hyperosmolar State. (Updated 2021 May 9). In:Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext (Internet). SouthDartmouth (MA): MDText.com, Inc.; 2000-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK279052/.
Perkeni. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia2021. Jakarta: PB Perkeni, 2021.
Adeyinka A, Kondamudi NP. Hyperglycemic Hyperosmolar Syndrome. (Updated2022 May 22). In: StatPearls (Internet). Treasure Island (FL): StatPearls Publishing;2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482142/.
French EK, Donihi AC, Korytkowski MT. Diabetic ketoacidosis and hyperosmolarhyperglycemic syndrome: review of acute decompensated diabetes in adult patients.BMJ 2019; 365. DOI: 10.1136/bmj.l1114.
Zamri A. Diagnosis dan Penatalaksanaan Hyperglycemic Hyperosmolar State (HHS).J Online Univ Jambi. 2019;7(2):151–60.
Evans K. Diabetic ketoacidosis: Update on management. Clin Med J R CollPhysicians London. 2019;19(5):396–8.
Lutfi EI. Perubahan Osmolaritas Pasien Hiperglikemia dengan Terapi Rehidrasi. JHolist Nurs Heal Sci. 2019;2(1):39–44.
Lutfi EI, Wihastuti TA, Kristianto H. Analisis Perubahan Hemodinamika Tubuh PadaPasien Hiperglikemia Dengan Terapi Rehidrasi Di Igd Rsud Dr. Iskak Tulung Agung.J Kesehat Mesencephalon. 2017;3(2):105–14.
Pasquel FJ, Umpierrez GE. Hyperglycemic Hyperosmolar state: A historic review ofthe clinical presentation, diagnosis, and treatment. Diabetes Care. 2014;37(11):3124–31.
Brown JPR, Douglas J. Hyperglycemic Hyperosmolar state. J Online Univ Jambi.2019;7(1):309–13.
Stoner GD. Hyperglycemic Hyperosmolar State. Am Fam Physician. 2017 Dec1;96(11):729-736. PMID: 29431405.
Kubacka BBT. Acute hyperglycemic emergencies: Diabetic ketoacidosis andHyperglycemic Hyperosmolar state. Nurs Crit Care. 2019;10(2).
Perkumpulan Endokrinologi Indonesia. Pedoman Petunjuk Praktis Terapi InsulinPada Pasien Diabetes Mellitus 2021. Pb Perkeni. 2021;42–6.
Kementrian Kesehatan RI. Keputusan Menteri Kesehatan RI NomorHK.01.07/MENKES/603/2020 tentang Pedoman Nasional Pelayanan Kedokteran TataLaksana Diabetes Melitus Tipe 2 Dewasa. 2020. Halaman 133-136. Available from :https://yankes.kemkes.go.id/unduhan/fileunduhan_1610340996_61925.pdf
Lizzo JM, Goyal A, Gupta V. Adult Diabetic Ketoacidosis. (Updated 2022 Jul 12). In:StatPearls (Internet). Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from; https://www.ncbi.nlm.nih.gov/books/NBK560723/
Scott AR; Joint British Diabetes Societies (JBDS) for Inpatient Care; JBDShyperosmolar hyperglycaemic guidelines group. Management of hyperosmolarhyperglycaemic state in adults with diabetes. Diabet Med. 2015 Jun;32(6):714-24. doi:10.1111/dme.12757. PMID: 25980647.
Van Ness-Otunnu, R., & Hack, J. B. (2013). Hyperglycemic Crisis. The Journal ofEmergency Medicine, 45(5), 797–805. doi:10.1016/j.jemermed.2013.03.040






