Efektivitas Ekstrak Daun Kelor ( Moringa Oleifera) terhadap Penurunan Kadar Kolesterol Total pada Tikus Putih ( Rattus Novergicus)

Abstract

Introduction: The prevalence of hypercholesterolemia in Indonesia is estimated to increased continously. One of the traditional medicines used to reduce blood cholesterol levels is Moringa oleifera Lam, After using the extract of Moringa leaves, the cholesterol levels slowly reduced, it because by the active substance component on Moringa leaves such as flavanoid, tannin saponin and β-sitosterol.

Objective : To determine the effect of Moringa leaf extract on reduce total cholesterol levels.

Methods : The research is an analytical research, using pre-experimental design with one group pre-test method post-test approach. By comparing treatment groups and control groups where the treatment group was treated on the form of Moringa leaf extract.

Results: The Paired T test showed that in the treatment group using Moringa leaf extract obtained before intervention the average cholesterol level was 307.40 mg/dl and after the interval was 209.00 mg/dl. Statistical test results obtained p value (0.00041) <0.05 which means that there is a difference of the mean cholesterol level between before and after treatment. Besides, the group using simvastatin was obtained before the intervention of the average cholesterol level was 271.20 mg/dl and after the interval was 127.40 mg/dl. Statistical test results obtained p value (0.009) <0.05 which means that there is a difference of the mean cholesterol level between before and after treatment.

Conclusion: There wasn’t any significant differences between the Moringa leaves and simvastatin use to reduce the total blood cholesterol levels.