Osteoporosis is a condition in which bone mass is reduced so that the tissue microarchitecture changes that lead to the risk of bone fragility fracture easily. This study aims to find out if there is a relationship between Body Mass Index (BMI) and osteoporosis in women of 50-60 years old. This study uses research methods Cross Sectional. Assessment of body weight and height was conducted on 29 subjects. The BMI was then determined. The subjects had thoracolumbal rontgen to assess the osteoporosis grading based on Genant method. Most of the subjects (13 or 44.8%) had normal BMI. Only a few samples had underweight and obesity condition (5 samples or 17.2% for each case). As for osteoporosis grading, most of the samples (15 or 51.7%) had 0 grading; and only 2 samples (6.9%) had 3 grading. It can be concluded that there is a significant relationship between BMI, and osteoporosis grading based on Genant method. The higher the BMI, the lower the Genant score will be.