Effect of Dangke on Changes in Neutrophil to Lymphocyte Ratio in Obese White Rats
DOI:
https://doi.org/10.33096/gmj.v6i1.158Keywords:
Dangke, neutrophil lymphocyte ratio, obesity, inflammationAbstract
Introduction: Obesity is associated with inflammation. Previous research has found that obesity determined by Body Mass Index (BMI) and Waist Circumference (LP) is associated with inflammation. Dangke contains Indigenos Lactic Acid Bacteria. The presence of lactic acid bacteria in fermented products has very positive benefits for health. The function of papaya sap which is used in making dangke, can act as an antibacterial and anti-inflammatory ingredient.
Methods: Pure experimental research with a design, namely Pre-Post Randomized Clinical Trial Design. Data analysis used the independent T-test/Mann-Whitney test with a value <0.05.
Results: The difference in the mean levels of Neutrophil to Lymphocyte (NLR) in the Intervention and control groups obtained a p-value of 0.94 which means that there is no relationship between control and intervention on NLR levels. The average change in NLR levels in the control group p-value of 0.61 which means there is no significant change in NLR levels in test 1 and test 2. The average change in NLR levels in the intervention group before and after the intervention was given a p-value of 0.07, which means there was no significant change in NLR levels in the intervention group.
Conclusion: This study showed that intervention with Dangke did not yield a significant alteration in the NLR levels within the animal model of obesity.
References
Parveen KZ, AvabrathaRodríguez-Rodríguez E, López-Sobaler AM, Ortega RM, Delgado-Losada ML, López-Parra AM, Aparicio A. Association between neutrophil-to-lymphocyte ratio with abdominal obesity and healthy eating index in a representative older Spanish population. Nutrients. 2020;12(3). doi:10.3390/nu1203085
Novri, SD Risk Factors for Obese Women in Lower Middle Socioeconomic Status, Thesis, Health Nutrition Study, Muhammadiyah University of Gresik. 2021;2(2):163-168.
Suryaalamsah Ii, Akbar Z, Harisatunnasyitoh Z, Et Al. Increasing Knowledge About Overweight and Obesity among Caregivers at the IGBS Darul Marhamah Islamic Boarding School, Jatisari Village, Cileungsi District, Bogor Regency, West Java. Proceedings of the National Seminar on Community Service LPPM Umj; 2019.
Wijayanti E, Retnoningrum D, Hendrianintyas M. The relationship between inflammatory markers and hemoglobin in obesity at the Faculty of Medicine, Diponegoro University for the period May-September 2018. DiscoverSys Digest of Medical Sciences. 2019;10(1):242-246. doi:10.1556/ism.v10i1.347
Sofia Yusnur Rafida, Hairuddin, Muhammad Hasan. Relationship Between Neutrophil-to-Lymphocyte Ratio (NLR) Values and Procalcitonin (PCT) Levels in COVID-19 Patients in Jember Regency. Andalas Medical Faculty Journal; 2022.
Aydın M, Ahsen Yilmaz, Feti Tulubas. Neutrophil lymphocyte ratio in obese adolescents. Northern Clinics of Istanbul. Published online 2019. doi:10.14744/nci.2015.25238.
Harun, A. 2022. Systematic Review: The Role of Neutrophil Cells in the Metabolic Disease Diabetes Mellitus Type 2. Faculty of Health Sciences. Aisyiyah University Yogyakarta; 2022.
Nugraha KA. Bacteriostatic and Bactericidal Agents in Dangke, Thesis, Fkg Hasanuddin University Makassar; 2021.
Rifah HA, Budiatman S, Harsi DK. Antibacterial Activation of Dried Papaya Sap Against Staphylococcus Aureus in Dangke. Journal of Technology and Food. Bogor Agricultural Institute. 2019;25(1).
Sulmiyati S, Said NS. Characteristics of Buffalo Milk Dangke with the Addition of Dry Papain Crude. agriTECH. 2019;38(3):345.
Bila Yunisa Tri Utami S, Ary Lantika U, Rachmi A. Scoping Review: Effectiveness of Consuming Probiotics on Body Weight in Overweight and Obese Adults. Bandung Conf Ser Med Sci. 2022;2(1):402–9.
PayamSharifan.Effectiveness of Low Fat Milk and Yogurt Enriched with Vitamin D3 on Systemic Inflammation in Adults with Abdominal Obesity. Journal of Health, Population and Nutrition.2022;41(8).
Nurwilda Kaswi. The Effect of Milk Type on Lactic Acid Bacteria Species in Dangke from Enrekang Regency. Faculty of Science and Technology, Uin Alauddin Makassar; 2020.
YuliatiWidiastuti.The Effect of Probiotic and Selenium Supplementation on the Immune Response of NLR (Neutrophil Lymphocyte Count Ratio), Hemoglobin and Albumin in Wistar Rats Induced by Mycobacterium Tuberculosis. Diponegoro University Faculty of Medicine;2019.
Nishimura Mie.Effects of Yogurt Containing Lactobacillus Plantarum HOKKAIDO on Immune Function and Stress Markers. Hokkaido Information University, Ebetsu, Hokkaido, Japan. 2019;6(3):275-277.
