Maternal Age Distribution of Down-Syndrome at Pediatric Growth and Development Clinic, 2015-2019


Musdalipa Musdalipa
Rini Wulandari
Martira Maddeppungeng


Introduction: Down Syndrome is a common chromosome abnormality among infants. This condition is Present in 1 over 800 deliveries. Advanced maternal age is a risk factor for Down syndrome. Other miscellaneous factors are radiation, infection, autoimmune and paternal age. The Aim is to determine maternal age distribution of Down syndrome at pediatric growth and development polyclinic, Wahidin Sudirohusodo hospital.

Methods: A Descriptive study. Study population was all outpatients at Pediatric Growth and Development polyclinic, Wahidin Sudirohusodo hospital in Makassar 2015-2019. Samples in this study were collected from total sampling of population data that met the criteria of new Down syndrome patients with complete medical records

Results: This study found 237 new pediatric down syndrome patients admitted to growth and development polyclinic from January 2015 – December 2019, 95 complete medical records from 237. 52% (49) boys, 48 % (46) girls from 95 children. No gender difference was found in the presentation. Parental age of Down syndrome patients, the most advanced maternal age was >35, found 46 (48,42%), the most advanced paternal age was >35, found 63 (66,32%).  Parity < 3rd, the most maternal age between 25-35 (23,16%), parity > 3rd, the most maternal age was >34, found 30 (31,57%).

Conclusion. Advance maternal and/ or paternal age is a risk factor of Down Syndrome.



1. Wayne H. Examination paediatrics 5th Edition A guide to paediatric training. Elsevier. 2019; 336-348
2. Soetjiningsih. Konsep Dasar Tumbuh Kembang Anak. In: Ranuh IGNG, penyunting. Tumbuh Kembang Anak. Edisi 2. Jakarta: EGC. 2017; 490-505.
3. William WH, Mayron JL, Robin RD, Mark JA, Current Diagnosis and treatment Pediatrics, 23nd edition (Lange). 2016; 1151.
4. Das H, Kusre G, Panyang R, Gogoi A, Shankarishan P, Nirmolia T. Study of the Relation of Maternal Age with Down Syndrome. International Journal of Health Information and Medical Research. 2(2): 9-12.
5. Sotonica M, Mackic-Djurovic M, Hasic S, Kiseljakovic E, Jadric R, Ibrulj S. Association of Parental Age and the Type of Down Syndrome on the Territory of Bosnia and Herzegovina. Med Arch. 2016; 70(2): 88-91.
6. Winurini S. Tantangan Pemerintah dalam mendukung penyandang Down Syndrome (DS) di Indonesia. Bidang Kesejahteraan Sosial, Info Singkat, Kajian Singkat Terhadap Isu Aktual dan Strategis. Jakarta: Pusat Penelitian Bidang Keahlian DPR RI. 2018; 10(6): 13-18.
7. Pusat data dan informasi kementerian kesehatan RI. Sindrom Down. 2018.
8. World Health Organization Regional Office for Europe (2018) Births with Down's syndrome per 100 000 live births. 2018. Available from:
9. Rayman R, Rahmanisa S, Putri GT, Hubungan Usia Ibu dengan Kejadian Sindrom Down. Medula. 2017; 7(5): 144-148.
10. Thompson JS. Disentangling the roles of maternal and paternal age on birth prevalence of Down syndrome and other chromosomal disorders using a Bayesian modeling approach. BMC Medical Research Methodology. 2019; 19:82. Available from:
11. Sharma R, Agarwal A, Rohra VK, Assidi M, Abu-Elmagd M, Turki RF. Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. Reprod Biol Endocrinol. 2015;13:35. doi: 10.1186/s12958-015-0028-x
12. Aldhwayan M, Al-Muammar MN, Alorf S, Am-Moajel A, El-Shafie M, Siddiqui AA, Khan F. Awareness among mothers of Down syndrome children on the importance of folic acid consumption during pregnancy. International Journal of Biomedical Research. 2015; 6(11): 903-908. DOI: .
13. Jyothy A, Rao GN, Kumar KS, Rao VB, Devi BU,Reddy PP. Translocation Down Syndrome. Indian J Med Sci. 2002; 56(3):122-126.
14. Abdullah AD, Abdulali AA, Abdulaziz AN, Mohammed SA, Seraj AA, Khaled AS dkk. Anemia and Other Hematologic Disorder in Children with Down Syndrome. EC Microbology 2019; 15(12): 1-7.
15. Nermine HA. Thyroid disorders in subjects with Down syndrome: an update. Acta Biomed. 2018; 89(1): 132-139. doi: 10.23750/abm.v89i1.7120.